Port St. Lucie Vacation Rentals

Compare 37 vacation rentals.
Home > USA > Florida > Port St. Lucie

Make Port St. Lucie your next getaway

Indulge in the ultimate coastal experience with a vacation rental in Port St. Lucie, Florida. Discover the perfect blend of sun-soaked beaches, exhilarating outdoor adventures, vibrant dining options, and endless possibilities for fun and relaxation. 

Top Port St. Lucie property types

housing_type_house.jpg

House rentals

View 33 House rentals
housing_type_apartment.jpg

Apartments

View 3 Apartments
housing_type_villa.jpg

Villas

View 1 Villas

Popular amenities for Port St. Lucie vacation rentals

Popular
Dog-friendly Hot tub Internet
Modern Port St Lucie Home w/ Private Outdoor Oasis
2 Bedroom | 2 Bath | Sleeps 10

Modern Port St Lucie Home w/ Private Outdoor Oasis - Port St. Lucie, FL

$297 avg / night
(excludes fees and taxes)
4.7 (10)
3-Acre Retreat, 3 Mi to Dtwn Jensen! Upscale Home
3 Bedroom | 2 Bath | Sleeps 6

3-Acre Retreat, 3 Mi to Dtwn Jensen! Upscale Home - Port St. Lucie, FL

$322 avg / night
(excludes fees and taxes)
5.0 (1)
2 Mi to City Center: Spacious Port St Lucie Home!
4 Bedroom | 3 Bath | Sleeps 12

2 Mi to City Center: Spacious Port St Lucie Home! - Port St. Lucie, FL

$276 avg / night
(excludes fees and taxes)
Private Pool & Hot Tub: Port St Lucie Escape
3 Bedroom | 2 Bath | Sleeps 10

Private Pool & Hot Tub: Port St Lucie Escape - Port St. Lucie, FL

$325 avg / night
(excludes fees and taxes)
4.89 (9)
Pet-Friendly Port St Lucie Home - 7 Mi to Beaches!
3 Bedroom | 2 Bath | Sleeps 6

Pet-Friendly Port St Lucie Home - 7 Mi to Beaches! - Port St. Lucie, FL

$218 avg / night
(excludes fees and taxes)
5.0 (4)

View 32 more homes

Browse more vacation rental amenities in Port St. Lucie

Pool | Electric vehicle charger | Lake view | Ocean view | Riverfront | Water view | Waterfront | A/C | Elevator | Washer/dryer

Recent Port St. Lucie guest reviews

Nice house. Very welcoming.
Leigha . | Apr 2026
We loved it! My family and I had a fabulous time. It was clean had basics the only thing it needs coolers and beach essentials 😁 we paid extra to get pool heated and that made the pool more enjoyable in evenings . Had plenty of entertainment options my boys loved the ping pong table kept them off electronics so I call it a win. We also enjoyed how private the backyard is and it's so close to a lot of shopping and restaurants.
Abigail . | Jan 2026
The house had everything we needed, and some things we didn't know we needed! It is beautifully decorated, and has many spaces to spread out from the amazing patio, large open kitchen, and huge sectional couch. Communication with the host was excellent, and all of our family members agreed it was the best rental we every had. Highly recommend!
Cindy . | Jan 2026
Port St. Lucie vacation rental FAQ

Yes, 7 of our Port St. Lucie homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 134 of our Port St. Lucie vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Port St. Lucie vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find the check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Port St. Lucie team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No problem, plans can change. For more information, please read our cancellation policy. If you have a Vacasa reservation for Port St. Lucie, log in to Trip Manager to explore the options available for your specific trip.

Book confidently. Stay comfortably.

Vacasa Guest Value Prop icon: 24-7
24/7 guest service
Vacasa Guest Value Prop Icon check-in
Seamless check-in
Vacasa Guest Value Prop Icons cleaning
Professional cleaning

Explore our Port St. Lucie, FL vacation rentals

You have choices when staying in one of our Port St. Lucie vacation rentals. Picture yourself lounging on pristine Atlantic beaches, taking part in thrilling water sports, exploring stunning nature preserves, and enjoying the city's renowned golf courses. Pick between charming Nettles Island condos for two or a private vacation home perfect for a family-friendly trip.

Port St. Lucie makes a fantastic home base to explore the Atlantic Coast. Savor fresh seafood at waterfront restaurants and immerse yourself in the lively atmosphere of this vibrant destination. No matter your choice, expect to spend your time in Florida relaxing or taking advantage of the excellent activities near your vacation rental.

What can you do in Port St. Lucie, FL?

You'll love how much Port St. Lucie has to offer, with endless family-friendly activities and relaxing coastal scenery. New to the area? Here are a few ideas to get your vacation started.

5 things to do in Port St. Lucie, FL

  1. Visit Jensen Beach Park or Stuart Beach
  2. Tee off at the Gator Trace Golf & Country Club
  3. Stroll through Indian Riverside Park
  4. Explore downtown Fort Pierce
  5. Get creative at the St. Lucie Performing Arts Center

Whether you seek outdoor adventures, leisurely beach days, or a lively atmosphere, Port St. Lucie is your gateway to an unforgettable vacation. Book your trip now and let the tropical beauty and endless possibilities of Port St. Lucie, Florida, sweep you off your feet.

Nearby destinations

Florida's Atlantic Coast   |   Southeast Florida   |   Treasure Coast   |   Jensen Beach   |   Stuart   |   Palm City   |   Fort Pierce   |   Hobe Sound   |   Vero Beach   |   Jupiter   |   Okeechobee   |   Florida
Show more