Lower Keys, FL Vacation Rentals

Compare 103 vacation rentals.
Home > USA > Florida > Lower Keys, FL

Make Lower Keys, FL your next getaway

When you’re looking for that perfect Florida Keys vacation rental, be sure to browse our Lower Keys beach houses and condos. Spanning the length of the legendary Overseas Highway, the Lower Keys area begins around Marathon and stretches to the southwest all the way to Key West. Whether you’re visiting for a weekend or the entire winter, a visit to a Lower Keys vacation rental guarantees tropical bliss.

Top Lower Keys, FL property types

housing_type_house.jpg

House rentals

View 42 House rentals
housing_type_condo.jpg

Condo rentals

View 36 Condo rentals
housing_type_apartment.jpg

Apartments

View 5 Apartments

Popular amenities for Lower Keys, FL vacation rentals

Popular
Dog-friendly Hot tub Internet
Amelia House
3 Bedroom | 2 Bath | Sleeps 6

Amelia House - Key West, FL

$531 avg / night
(excludes fees and taxes)
4.36 (122)
Tradewinds
4 Bedroom | 2 Bath | Sleeps 12

Tradewinds - Key West, FL

$744 avg / night
(excludes fees and taxes)
4.38 (65)
Old Town Garden Villas - Abaco Suite
1 Bedroom | 1.5 Bath | Sleeps 4

Old Town Garden Villas - Abaco Suite - Key West, FL

$399 avg / night
(excludes fees and taxes)
4.66 (131)
Sunrise Suites - Dominican Suite 110
2 Bedroom | 2 Bath | Sleeps 6

Sunrise Suites - Dominican Suite 110 - Key West, FL

$310 avg / night
(excludes fees and taxes)
4.39 (112)
Sunrise Suites - Cozumel Suite 112
2 Bedroom | 2 Bath | Sleeps 6

Sunrise Suites - Cozumel Suite 112 - Key West, FL

$275 avg / night
(excludes fees and taxes)
4.3 (133)

View 98 more homes

Recent Lower Keys, FL guest reviews

We had a great stay at Amelia House. There was plenty of room for our group of 6 and the house was nicely stocked with all of the essentials. The location was unbeatable and walkable to great restaurants, bars, and the water. We would definitely stay again.
Macy S. | Mar 2026
Great location on a private street right off Duval. The back patio is a great spot to relax. The pool house was very nice. Good place for 4-6 adults.
BRIAN B. | Mar 2026
Very nice facility. Clean and very comfy with 2 bedrooms.
katie f. | Mar 2026
Lower Keys, FL vacation rental FAQ

Yes, 43 of our Lower Keys, FL homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 103 of our Lower Keys, FL vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Lower Keys, FL vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find the check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Lower Keys, FL team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No problem, plans can change. For more information, please read our cancellation policy. If you have a Vacasa reservation for Lower Keys, FL, log in to Trip Manager to explore the options available for your specific trip.

Book confidently. Stay comfortably.

Vacasa Guest Value Prop icon: 24-7
24/7 guest service
Vacasa Guest Value Prop Icon check-in
Seamless check-in
Vacasa Guest Value Prop Icons cleaning
Professional cleaning


Marathon and Key Colony Beach: the gateway to the Lower Keys


The town of Marathon, which technically encompasses several keys, is one of the most popular destinations in the Florida Keys. Key Colony Beach, the hub of Marathon, is home to several beautiful stretches of shoreline, as well as plenty of docks, restaurants, and luxurious vacation rentals to choose from. Like everywhere in the Lower Keys, the fishing and snorkeling surrounding Marathon are superb, so don’t be afraid to get out on the waves!

Cudjoe Key, the Torch Keys, and Sugarloaf Key


Cross the Seven Mile Bridge, and you’ll find the hidden gems of the Lower Keys: the Torch Keys, Cudjoe Key, and Sugarloaf Key. These less populous parts of the Keys are home to some of our most secluded and beautiful Florida Keys vacation rentals, some of which are beachfront---an amenity in hot demand in the Lower Keys. Find your own little corner of paradise here, and you’re just a short car trip away from the hustle and bustle of Key West or Marathon.

Key West: the southern end of the Lower Keys


Colloquially recognized as the United States’ Southernmost Point, Key West is a historic and beautiful spot for a Keys getaway. Many of our Key West vacation rentals boast private pools, luxurious interiors, spacious patios, and rich history. Duval Street is the hub of most of the town’s action, with plenty of shopping, dining, and entertainment choices. Book a fishing excursion or sailing charter and enjoy the crystal-blue waters that surround you, or rent snorkeling gear and experience the area’s renowned coral reefs. A Key West vacation rental is the perfect place to spend the whole winter---snowbirds are welcome!

No matter where you're headed in the Lower Keys, we have a picturesque vacation home waiting for you. Book today!