Seneca Vacation Rentals

Compare 23 vacation rentals.
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Make Seneca your next getaway

Explore our vacation rentals Seneca South Carolina. Our private accommodations include everything you need to have the perfect getaway, whether you're here for a family vacation, couples retreat, or making memories with friends.

Top Seneca property types

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House rentals

View 14 House rentals
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Apartments

View 9 Apartments

Popular amenities for Seneca vacation rentals

Popular
Dog-friendly Hot tub Internet
Lake Keowee Home with Balcony & Boat Dock!
5 Bedroom | 5 Bath | Sleeps 14

Lake Keowee Home with Balcony & Boat Dock! - Seneca, SC

$1,127 avg / night
(excludes fees and taxes)
5.0 (25)
Lake Keowee Home:Sleeps 7,Lake Access,Coffee Bar
3 Bedroom | 2 Bath | Sleeps 7

Lake Keowee Home:Sleeps 7,Lake Access,Coffee Bar - Seneca, SC

$224 avg / night
(excludes fees and taxes)
1.0 (1)
7 Mi to Clemson Stadiums: Lake Keowee Getaway!
2 Bedroom | 2 Bath | Sleeps 6

7 Mi to Clemson Stadiums: Lake Keowee Getaway! - Seneca, SC

$278 avg / night
(excludes fees and taxes)
6 Mi to South Cove Boat Ramp! Lake Keowee Escape
2 Bedroom | 1 Bath | Sleeps 4

6 Mi to South Cove Boat Ramp! Lake Keowee Escape - Seneca, SC

$365 avg / night
(excludes fees and taxes)
Newry Retreat in Converted Church w/ Shared Patio!
2 Bedroom | 1 Bath | Sleeps 4

Newry Retreat in Converted Church w/ Shared Patio! - Seneca, SC

$224 avg / night
(excludes fees and taxes)
5.0 (2)

View 18 more homes

Recent Seneca guest reviews

Awesome time, plenty of room for our party of 12. Kids game tables were in rough shape but usable. Perfect weather for our stay, water was swimable but murky. Kayaking and jumping off 2nd level dock was fun but be mindful of slivers, highly recommend water shoes. Stairs to the beach are not ideal for elderly or very young so plan accordingly. Will definitely rent this location again.
Ronald . | May 2026
It was amazing! My family loved the house-peaceful, quiet yet still close to many restaurants and grocery stores. We loved the basement-perfect for family game nights.
Cece . | Apr 2026
Can’t say how comfortable this home is for our football family. Oh, the back porch fun we had! Each bedroom is perfect for our families and offers lots of options for kids and adults. Thanks again!!
Sarah . | Nov 2025
Seneca vacation rental FAQ

Yes, 9 of our Seneca homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 93 of our Seneca vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Seneca vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find the check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Seneca team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No problem, plans can change. For more information, please read our cancellation policy. If you have a Vacasa reservation for Seneca, log in to Trip Manager to explore the options available for your specific trip.

Book confidently. Stay comfortably.

Vacasa Guest Value Prop icon: 24-7
24/7 guest service
Vacasa Guest Value Prop Icon check-in
Seamless check-in
Vacasa Guest Value Prop Icons cleaning
Professional cleaning