Lower Keys, FL Vacation Rentals

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Make Lower Keys, FL your next getaway

When you’re looking for that perfect Florida Keys vacation rental, be sure to browse our Lower Keys beach houses and condos. Spanning the length of the legendary Overseas Highway, the Lower Keys area begins around Marathon and stretches to the southwest all the way to Key West. Whether you’re visiting for a weekend or the entire winter, a visit to a Lower Keys vacation rental guarantees tropical bliss.

Top Lower Keys, FL property types

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House rentals

View 42 House rentals
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Condo rentals

View 36 Condo rentals
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Apartments

View 5 Apartments

Popular amenities for Lower Keys, FL vacation rentals

Popular
Dog-friendly Hot tub Internet
Old Town Garden Villas - Andros Suite
1 Bedroom | 1.5 Bath | Sleeps 4

Old Town Garden Villas - Andros Suite - Key West, FL

$304 avg / night
(excludes fees and taxes)
4.73 (150)
Sunrise Suites - Panama Suite 310
2 Bedroom | 2 Bath | Sleeps 4

Sunrise Suites - Panama Suite 310 - Key West, FL

$258 avg / night
(excludes fees and taxes)
4.48 (152)
Old Town Garden Villas - Abaco Suite
1 Bedroom | 1.5 Bath | Sleeps 4

Old Town Garden Villas - Abaco Suite - Key West, FL

$395 avg / night
(excludes fees and taxes)
4.66 (131)
Conch Casa
2 Bedroom | 1 Bath | Sleeps 6

Conch Casa - Key West, FL

$479 avg / night
(excludes fees and taxes)
4.47 (132)
Sunrise Suites - Cozumel Suite 112
2 Bedroom | 2 Bath | Sleeps 6

Sunrise Suites - Cozumel Suite 112 - Key West, FL

$241 avg / night
(excludes fees and taxes)
4.3 (134)

View 98 more homes

Browse more vacation rental amenities in Lower Keys, FL

Pool | Lake view | Ocean view | Oceanfront | Sound view | Soundfront | Water view | Waterfront | A/C | Elevator

Recent Lower Keys, FL guest reviews

When originally booking this home, I read a lot of reviews good and bad on other platforms. Cleanliness and upkeep to an older cottage were the main recurring issues. I reached out to property management and they were careful enough in reassuring me of my concerns they responded by Email and phone months in advance of our reservation and were reachable just before and during our stay. None of the deficiencies I had come across in reviews over past years seem to still exist. Which tells me the owner and management pay attention and fix problems. Was a very clean and lovely stay. They best location. Very clean. Mind you, it isn't new. It's an older cottage. Vacasa office is across the street. They were very helpful with recommendations and holding our bags before check in and after check out. I think in general a 4 pm checkin could be 3pm and a 10 am check out could be an 11am. The cleaners were a little too eager. They were there at 9:55am already trying to get in when when we were still moving our suitcases to the front door.
Evan F. | Mar 2026
Wonderful location
jason a. | Mar 2026
We absolutely loved our stay here in Key West! It was perfect for us and so incredibly cute—exactly the vibe we were hoping for. The bathroom was spacious and beautifully done, which made getting ready feel a little extra luxurious. The bed was amazing—super comfortable and honestly one of the best parts after long days of exploring. The kitchen was just what we needed. We didn’t do a ton of cooking, but having a fridge was a game changer for drinks, snacks, and leftovers. Everything felt clean, well-kept, and thoughtfully put together. The location was also great—close enough to everything we wanted to do, but still felt like a relaxing little escape. Overall, it was the perfect spot for our trip and we would definitely stay here again!
Morgan B. | Mar 2026
Lower Keys, FL vacation rental FAQ

Yes, 40 of our Lower Keys, FL homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 103 of our Lower Keys, FL vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Lower Keys, FL vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find the check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Lower Keys, FL team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No problem, plans can change. For more information, please read our cancellation policy. If you have a Vacasa reservation for Lower Keys, FL, log in to Trip Manager to explore the options available for your specific trip.

Book confidently. Stay comfortably.

Vacasa Guest Value Prop icon: 24-7
24/7 guest service
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Seamless check-in
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Professional cleaning


Marathon and Key Colony Beach: the gateway to the Lower Keys


The town of Marathon, which technically encompasses several keys, is one of the most popular destinations in the Florida Keys. Key Colony Beach, the hub of Marathon, is home to several beautiful stretches of shoreline, as well as plenty of docks, restaurants, and luxurious vacation rentals to choose from. Like everywhere in the Lower Keys, the fishing and snorkeling surrounding Marathon are superb, so don’t be afraid to get out on the waves!

Cudjoe Key, the Torch Keys, and Sugarloaf Key


Cross the Seven Mile Bridge, and you’ll find the hidden gems of the Lower Keys: the Torch Keys, Cudjoe Key, and Sugarloaf Key. These less populous parts of the Keys are home to some of our most secluded and beautiful Florida Keys vacation rentals, some of which are beachfront---an amenity in hot demand in the Lower Keys. Find your own little corner of paradise here, and you’re just a short car trip away from the hustle and bustle of Key West or Marathon.

Key West: the southern end of the Lower Keys


Colloquially recognized as the United States’ Southernmost Point, Key West is a historic and beautiful spot for a Keys getaway. Many of our Key West vacation rentals boast private pools, luxurious interiors, spacious patios, and rich history. Duval Street is the hub of most of the town’s action, with plenty of shopping, dining, and entertainment choices. Book a fishing excursion or sailing charter and enjoy the crystal-blue waters that surround you, or rent snorkeling gear and experience the area’s renowned coral reefs. A Key West vacation rental is the perfect place to spend the whole winter---snowbirds are welcome!

No matter where you're headed in the Lower Keys, we have a picturesque vacation home waiting for you. Book today!

Nearby destinations

Gulf Coast   |   Florida's Atlantic Coast   |   South Florida   |   Southeast Florida   |   Florida Keys   |   Old Town Key West   |   Mallory Square - Key West   |   Bahama Village - Key West   |   Historic Key West   |   Sunrise Suites Resort - Key West   |   Papa's Hideaway - Key West, FL   |   Shipyard Condos - Key West   |   Stock Island   |   Saddlebunch Keys   |   Duval Square - Key West   |   Tropical Village - Key West   |   Cudjoe Key   |   Big Pine Key   |   Ramrod Key   |   Sugarloaf Key   |   Summerland Key   |   Little Torch Key   |   Key West   |   Florida
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